1T6F | pdb_00001t6f

Crystal Structure of the Coiled-coil Dimerization Motif of Geminin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1t6fa_	Coiled coil proteins	Parallel coiled-coil	Geminin coiled-coil domain	Geminin coiled-coil domain	Geminin coiled-coil domain	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1t6fb_	Coiled coil proteins	Parallel coiled-coil	Geminin coiled-coil domain	Geminin coiled-coil domain	Geminin coiled-coil domain	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Geminin coiled-coil domain	8027652	4003113	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Geminin coiled-coil domain	8040031	3000277	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Geminin coiled-coil domain	8040031	3000277	SCOP2B (2022-06-29)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Geminin	transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity transcription factor binding protein binding binding DNA-binding transcription factor binding histone deacetylase binding enzyme binding chromatin binding	DNA-templated DNA replication protein-containing complex organization DNA replication preinitiation complex assembly nuclear DNA replication cell cycle DNA replication primary metabolic process protein-DNA complex assembly DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization DNA replication cellular component assembly DNA-templated DNA replication protein-containing complex organization DNA replication preinitiation complex assembly nuclear DNA replication cell cycle DNA replication primary metabolic process protein-DNA complex assembly DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization DNA replication cellular component assembly protein-containing complex assembly metabolic process cellular process macromolecule metabolic process cell cycle cellular component organization or biogenesis cell cycle process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process regulation of mitotic cell cycle regulation of cell cycle mitotic cell cycle developmental process anatomical structure morphogenesis anatomical structure development animal organ development animal organ morphogenesis regulation of DNA replication regulation of DNA metabolic process negative regulation of cell cycle negative regulation of DNA-templated DNA replication negative regulation of DNA replication regulation of DNA-templated DNA replication negative regulation of DNA metabolic process positive regulation of chromatin binding positive regulation of molecular function regulation of molecular function regulation of binding positive regulation of binding regulation of DNA-templated DNA replication initiation DNA replication initiation	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex transcription regulator complex transcription repressor complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex transcription regulator complex transcription repressor complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR022786	Geminin/Multicilin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O75496	Meier-Gorlin syndrome Meier-Gorlin syndrome 6 pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome adrenal cortex carcinoma EAR, PATELLA, SHORT STATURE SYNDROME interstitial cystitis lymphoplasmacytic lymphoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma polycystic ovary syndrome astrocytic tumor glioblastoma lung adenocarcinoma malignant mesothelioma Meier-Gorlin syndrome Meier-Gorlin syndrome 6 pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome adrenal cortex carcinoma EAR, PATELLA, SHORT STATURE SYNDROME interstitial cystitis lymphoplasmacytic lymphoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma polycystic ovary syndrome astrocytic tumor glioblastoma lung adenocarcinoma malignant mesothelioma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm breast fibroadenoma hepatocellular carcinoma lung cancer malignant pancreatic neoplasm nasopharyngeal carcinoma pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.