Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1pkla1 All beta proteins PK beta-barrel domain-like PK beta-barrel domain-like Pyruvate kinase beta-barrel domain Pyruvate kinase (PK) (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
Ad1pkla2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Phosphoenolpyruvate/pyruvate domain Pyruvate kinase Pyruvate kinase, N-terminal domain (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
Ad1pkla3 Alpha and beta proteins (a/b) Pyruvate kinase C-terminal domain-like PK C-terminal domain-like Pyruvate kinase, C-terminal domain Pyruvate kinase, C-terminal domain (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
Cd1pklc1 All beta proteins PK beta-barrel domain-like PK beta-barrel domain-like Pyruvate kinase beta-barrel domain Pyruvate kinase (PK) (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
Cd1pklc2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Phosphoenolpyruvate/pyruvate domain Pyruvate kinase Pyruvate kinase, N-terminal domain (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
Cd1pklc3 Alpha and beta proteins (a/b) Pyruvate kinase C-terminal domain-like PK C-terminal domain-like Pyruvate kinase, C-terminal domain Pyruvate kinase, C-terminal domain (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
Dd1pkld1 All beta proteins PK beta-barrel domain-like PK beta-barrel domain-like Pyruvate kinase beta-barrel domain Pyruvate kinase (PK) (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
Dd1pkld2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Phosphoenolpyruvate/pyruvate domain Pyruvate kinase Pyruvate kinase, N-terminal domain (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
Dd1pkld3 Alpha and beta proteins (a/b) Pyruvate kinase C-terminal domain-like PK C-terminal domain-like Pyruvate kinase, C-terminal domain Pyruvate kinase, C-terminal domain (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
Ed1pkle1 All beta proteins PK beta-barrel domain-like PK beta-barrel domain-like Pyruvate kinase beta-barrel domain Pyruvate kinase (PK) (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
Ed1pkle2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Phosphoenolpyruvate/pyruvate domain Pyruvate kinase Pyruvate kinase, N-terminal domain (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
Ed1pkle3 Alpha and beta proteins (a/b) Pyruvate kinase C-terminal domain-like PK C-terminal domain-like Pyruvate kinase, C-terminal domain Pyruvate kinase, C-terminal domain (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
Fd1pklf1 All beta proteins PK beta-barrel domain-like PK beta-barrel domain-like Pyruvate kinase beta-barrel domain Pyruvate kinase (PK) (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
Fd1pklf2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Phosphoenolpyruvate/pyruvate domain Pyruvate kinase Pyruvate kinase, N-terminal domain (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
Fd1pklf3 Alpha and beta proteins (a/b) Pyruvate kinase C-terminal domain-like PK C-terminal domain-like Pyruvate kinase, C-terminal domain Pyruvate kinase, C-terminal domain (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
G [auth H]d1pklh1 All beta proteins PK beta-barrel domain-like PK beta-barrel domain-like Pyruvate kinase beta-barrel domain Pyruvate kinase (PK) (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
G [auth H]d1pklh2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Phosphoenolpyruvate/pyruvate domain Pyruvate kinase Pyruvate kinase, N-terminal domain (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
G [auth H]d1pklh3 Alpha and beta proteins (a/b) Pyruvate kinase C-terminal domain-like PK C-terminal domain-like Pyruvate kinase, C-terminal domain Pyruvate kinase, C-terminal domain (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
H [auth G]d1pklg1 All beta proteins PK beta-barrel domain-like PK beta-barrel domain-like Pyruvate kinase beta-barrel domain Pyruvate kinase (PK) (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
H [auth G]d1pklg2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Phosphoenolpyruvate/pyruvate domain Pyruvate kinase Pyruvate kinase, N-terminal domain (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
H [auth G]d1pklg3 Alpha and beta proteins (a/b) Pyruvate kinase C-terminal domain-like PK C-terminal domain-like Pyruvate kinase, C-terminal domain Pyruvate kinase, C-terminal domain (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
Bd1pklb1 All beta proteins PK beta-barrel domain-like PK beta-barrel domain-like Pyruvate kinase beta-barrel domain Pyruvate kinase (PK) (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
Bd1pklb2 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Phosphoenolpyruvate/pyruvate domain Pyruvate kinase Pyruvate kinase, N-terminal domain (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)
Bd1pklb3 Alpha and beta proteins (a/b) Pyruvate kinase C-terminal domain-like PK C-terminal domain-like Pyruvate kinase, C-terminal domain Pyruvate kinase, C-terminal domain (Leishmania mexicana ) [TaxId: 5665 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPK C-terminal domain-like 8044406 3000442 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPK beta-barrel domain-like 8042557 3001296 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPK beta-barrel domain-like 8042557 3001296 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPK C-terminal domain-like 8044406 3000442 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyPK beta-barrel domain-like 8042557 3001296 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyPK C-terminal domain-like 8044406 3000442 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyPK C-terminal domain-like 8044406 3000442 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyPK beta-barrel domain-like 8042557 3001296 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyPK beta-barrel domain-like 8042557 3001296 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyPK C-terminal domain-like 8044406 3000442 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
G [auth H]SCOP2B SuperfamilyPK beta-barrel domain-like 8042557 3001296 SCOP2B (2022-06-29)
G [auth H]SCOP2B SuperfamilyPK C-terminal domain-like 8044406 3000442 SCOP2B (2022-06-29)
G [auth H]SCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
G [auth H]SCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
H [auth G]SCOP2 FamilyPyruvate kinase beta-barrel domain 8030178 4002474 SCOP2 (2022-06-29)
H [auth G]SCOP2 FamilyPyruvate kinase 8031271 4003255 SCOP2 (2022-06-29)
H [auth G]SCOP2 FamilyPK C-terminal domain-like 8032028 4000500 SCOP2 (2022-06-29)
H [auth G]SCOP2 SuperfamilyPK beta-barrel domain-like 8042557 3001296 SCOP2 (2022-06-29)
H [auth G]SCOP2 SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2 (2022-06-29)
H [auth G]SCOP2 SuperfamilyPK C-terminal domain-like 8044406 3000442 SCOP2 (2022-06-29)
BSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPhosphoenolpyruvate/pyruvate domain 8043649 3000510 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPK C-terminal domain-like 8044406 3000442 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPK beta-barrel domain-like 8042557 3001296 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APK_2nde1pklA1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PK beta-barrel domain-likeF: PK_2ndECOD (1.6)
APK_1ste1pklA2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PK_1stECOD (1.6)
APK_Ce1pklA3 A: a/b three-layered sandwichesX: PK C-terminal domain-like (From Topology)H: PK C-terminal domain-like (From Topology)T: PK C-terminal domain-likeF: PK_CECOD (1.6)
CPK_2nde1pklC4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PK beta-barrel domain-likeF: PK_2ndECOD (1.6)
CPK_1ste1pklC2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PK_1stECOD (1.6)
CPK_Ce1pklC1 A: a/b three-layered sandwichesX: PK C-terminal domain-like (From Topology)H: PK C-terminal domain-like (From Topology)T: PK C-terminal domain-likeF: PK_CECOD (1.6)
DPK_2nde1pklD4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PK beta-barrel domain-likeF: PK_2ndECOD (1.6)
DPK_1ste1pklD2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PK_1stECOD (1.6)
DPK_Ce1pklD1 A: a/b three-layered sandwichesX: PK C-terminal domain-like (From Topology)H: PK C-terminal domain-like (From Topology)T: PK C-terminal domain-likeF: PK_CECOD (1.6)
EPK_2nde1pklE4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PK beta-barrel domain-likeF: PK_2ndECOD (1.6)
EPK_1ste1pklE2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PK_1stECOD (1.6)
EPK_Ce1pklE1 A: a/b three-layered sandwichesX: PK C-terminal domain-like (From Topology)H: PK C-terminal domain-like (From Topology)T: PK C-terminal domain-likeF: PK_CECOD (1.6)
FPK_2nde1pklF4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PK beta-barrel domain-likeF: PK_2ndECOD (1.6)
FPK_1ste1pklF2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PK_1stECOD (1.6)
FPK_Ce1pklF1 A: a/b three-layered sandwichesX: PK C-terminal domain-like (From Topology)H: PK C-terminal domain-like (From Topology)T: PK C-terminal domain-likeF: PK_CECOD (1.6)
G [auth H]PK_2nde1pklH4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PK beta-barrel domain-likeF: PK_2ndECOD (1.6)
G [auth H]PK_1ste1pklH2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PK_1stECOD (1.6)
G [auth H]PK_Ce1pklH1 A: a/b three-layered sandwichesX: PK C-terminal domain-like (From Topology)H: PK C-terminal domain-like (From Topology)T: PK C-terminal domain-likeF: PK_CECOD (1.6)
H [auth G]PK_2nde1pklG4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PK beta-barrel domain-likeF: PK_2ndECOD (1.6)
H [auth G]PK_1ste1pklG2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PK_1stECOD (1.6)
H [auth G]PK_Ce1pklG1 A: a/b three-layered sandwichesX: PK C-terminal domain-like (From Topology)H: PK C-terminal domain-like (From Topology)T: PK C-terminal domain-likeF: PK_CECOD (1.6)
BPK_2nde1pklB4 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: PK beta-barrel domain-likeF: PK_2ndECOD (1.6)
BPK_1ste1pklB2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: PK_1stECOD (1.6)
BPK_Ce1pklB1 A: a/b three-layered sandwichesX: PK C-terminal domain-like (From Topology)H: PK C-terminal domain-like (From Topology)T: PK C-terminal domain-likeF: PK_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.1380.20 Alpha Beta 3-Layer(aba) Sandwich Pyruvate Kinase Chain: A, domain 1CATH (4.3.0)
A3.20.20.60 Alpha Beta Alpha-Beta Barrel TIM Barrel Phosphoenolpyruvate-binding domainsCATH (4.3.0)
A2.40.33.10 Mainly Beta Beta Barrel M1 Pyruvate Kinase Domain 3CATH (4.3.0)
C3.40.1380.20 Alpha Beta 3-Layer(aba) Sandwich Pyruvate Kinase Chain: A, domain 1CATH (4.3.0)
C3.20.20.60 Alpha Beta Alpha-Beta Barrel TIM Barrel Phosphoenolpyruvate-binding domainsCATH (4.3.0)
C2.40.33.10 Mainly Beta Beta Barrel M1 Pyruvate Kinase Domain 3CATH (4.3.0)
D3.40.1380.20 Alpha Beta 3-Layer(aba) Sandwich Pyruvate Kinase Chain: A, domain 1CATH (4.3.0)
D3.20.20.60 Alpha Beta Alpha-Beta Barrel TIM Barrel Phosphoenolpyruvate-binding domainsCATH (4.3.0)
D2.40.33.10 Mainly Beta Beta Barrel M1 Pyruvate Kinase Domain 3CATH (4.3.0)
E3.40.1380.20 Alpha Beta 3-Layer(aba) Sandwich Pyruvate Kinase Chain: A, domain 1CATH (4.3.0)
E3.20.20.60 Alpha Beta Alpha-Beta Barrel TIM Barrel Phosphoenolpyruvate-binding domainsCATH (4.3.0)
E2.40.33.10 Mainly Beta Beta Barrel M1 Pyruvate Kinase Domain 3CATH (4.3.0)
F3.40.1380.20 Alpha Beta 3-Layer(aba) Sandwich Pyruvate Kinase Chain: A, domain 1CATH (4.3.0)
F3.20.20.60 Alpha Beta Alpha-Beta Barrel TIM Barrel Phosphoenolpyruvate-binding domainsCATH (4.3.0)
F2.40.33.10 Mainly Beta Beta Barrel M1 Pyruvate Kinase Domain 3CATH (4.3.0)
G [auth H]3.40.1380.20 Alpha Beta 3-Layer(aba) Sandwich Pyruvate Kinase Chain: A, domain 1CATH (4.3.0)
G [auth H]3.20.20.60 Alpha Beta Alpha-Beta Barrel TIM Barrel Phosphoenolpyruvate-binding domainsCATH (4.3.0)
G [auth H]2.40.33.10 Mainly Beta Beta Barrel M1 Pyruvate Kinase Domain 3CATH (4.3.0)
H [auth G]3.40.1380.20 Alpha Beta 3-Layer(aba) Sandwich Pyruvate Kinase Chain: A, domain 1CATH (4.3.0)
H [auth G]3.20.20.60 Alpha Beta Alpha-Beta Barrel TIM Barrel Phosphoenolpyruvate-binding domainsCATH (4.3.0)
H [auth G]2.40.33.10 Mainly Beta Beta Barrel M1 Pyruvate Kinase Domain 3CATH (4.3.0)
B3.40.1380.20 Alpha Beta 3-Layer(aba) Sandwich Pyruvate Kinase Chain: A, domain 1CATH (4.3.0)
B3.20.20.60 Alpha Beta Alpha-Beta Barrel TIM Barrel Phosphoenolpyruvate-binding domainsCATH (4.3.0)
B2.40.33.10 Mainly Beta Beta Barrel M1 Pyruvate Kinase Domain 3CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A,
B,
C,
D,
E,
PF00224Pyruvate kinase, barrel domain (PK)Pyruvate kinase, barrel domainThis is the barrel domain of pyruvate kinases. This domain represents the beta/alpha barrel and the small beta-barrel domain inserted within it. The active site is found in a cleft between the two domains [1,2,3,4].Domain
A,
B,
C,
D,
E,
PF02887Pyruvate kinase, alpha/beta domain (PK_C)Pyruvate kinase, alpha/beta domainPyruvate kinase catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP [1,2]. The structure of several pyruvate kinases from various organisms have been determined [2, ...Pyruvate kinase catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP [1,2]. The structure of several pyruvate kinases from various organisms have been determined [2, 3,4]. The protein comprises three-four domains: a small N-terminal helical domain (absent in bacterial PK), a beta/alpha barrel domain, a beta-barrel domain (inserted within the beta/alpha-barrel domain), and a 3-layer alpha/beta/alpha sandwich domain (represented in this entry). This domain is at the C-terminal of pyruvate kinases and contains the FBP (fructose 1,6-bisphosphate) binding site [2,4,5].
Domain