1PKL
THE STRUCTURE OF LEISHMANIA PYRUVATE KINASE
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | PK C-terminal domain-like | 8044406 | 3000442 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | PK beta-barrel domain-like | 8042557 | 3001296 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | PK C-terminal domain-like | 8044406 | 3000442 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | PK beta-barrel domain-like | 8042557 | 3001296 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | PK beta-barrel domain-like | 8042557 | 3001296 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | PK C-terminal domain-like | 8044406 | 3000442 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | PK C-terminal domain-like | 8044406 | 3000442 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | PK beta-barrel domain-like | 8042557 | 3001296 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
G [auth H] | SCOP2B Superfamily | PK beta-barrel domain-like | 8042557 | 3001296 | SCOP2B (2022-06-29) |
G [auth H] | SCOP2B Superfamily | PK C-terminal domain-like | 8044406 | 3000442 | SCOP2B (2022-06-29) |
G [auth H] | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
G [auth H] | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
H [auth G] | SCOP2 Family | Pyruvate kinase beta-barrel domain | 8030178 | 4002474 | SCOP2 (2022-06-29) |
H [auth G] | SCOP2 Family | Pyruvate kinase | 8031271 | 4003255 | SCOP2 (2022-06-29) |
H [auth G] | SCOP2 Family | PK C-terminal domain-like | 8032028 | 4000500 | SCOP2 (2022-06-29) |
H [auth G] | SCOP2 Superfamily | PK beta-barrel domain-like | 8042557 | 3001296 | SCOP2 (2022-06-29) |
H [auth G] | SCOP2 Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2 (2022-06-29) |
H [auth G] | SCOP2 Superfamily | PK C-terminal domain-like | 8044406 | 3000442 | SCOP2 (2022-06-29) |
C | SCOP2B Superfamily | PK beta-barrel domain-like | 8042557 | 3001296 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | PK C-terminal domain-like | 8044406 | 3000442 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
F | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
F | SCOP2B Superfamily | PK beta-barrel domain-like | 8042557 | 3001296 | SCOP2B (2022-06-29) |
F | SCOP2B Superfamily | PK C-terminal domain-like | 8044406 | 3000442 | SCOP2B (2022-06-29) |
F | SCOP2B Superfamily | Phosphoenolpyruvate/pyruvate domain | 8043649 | 3000510 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PK_2nd | e1pklA1 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: PK beta-barrel domain-like | F: PK_2nd | ECOD (1.6) |
A | PK_1st | e1pklA2 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: PK_1st | ECOD (1.6) |
A | PK_C | e1pklA3 | A: a/b three-layered sandwiches | X: PK C-terminal domain-like (From Topology) | H: PK C-terminal domain-like (From Topology) | T: PK C-terminal domain-like | F: PK_C | ECOD (1.6) |
B | PK_2nd | e1pklB4 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: PK beta-barrel domain-like | F: PK_2nd | ECOD (1.6) |
B | PK_1st | e1pklB2 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: PK_1st | ECOD (1.6) |
B | PK_C | e1pklB1 | A: a/b three-layered sandwiches | X: PK C-terminal domain-like (From Topology) | H: PK C-terminal domain-like (From Topology) | T: PK C-terminal domain-like | F: PK_C | ECOD (1.6) |
D | PK_2nd | e1pklD4 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: PK beta-barrel domain-like | F: PK_2nd | ECOD (1.6) |
D | PK_1st | e1pklD2 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: PK_1st | ECOD (1.6) |
D | PK_C | e1pklD1 | A: a/b three-layered sandwiches | X: PK C-terminal domain-like (From Topology) | H: PK C-terminal domain-like (From Topology) | T: PK C-terminal domain-like | F: PK_C | ECOD (1.6) |
E | PK_2nd | e1pklE4 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: PK beta-barrel domain-like | F: PK_2nd | ECOD (1.6) |
E | PK_1st | e1pklE2 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: PK_1st | ECOD (1.6) |
E | PK_C | e1pklE1 | A: a/b three-layered sandwiches | X: PK C-terminal domain-like (From Topology) | H: PK C-terminal domain-like (From Topology) | T: PK C-terminal domain-like | F: PK_C | ECOD (1.6) |
G [auth H] | PK_2nd | e1pklH4 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: PK beta-barrel domain-like | F: PK_2nd | ECOD (1.6) |
G [auth H] | PK_1st | e1pklH2 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: PK_1st | ECOD (1.6) |
G [auth H] | PK_C | e1pklH1 | A: a/b three-layered sandwiches | X: PK C-terminal domain-like (From Topology) | H: PK C-terminal domain-like (From Topology) | T: PK C-terminal domain-like | F: PK_C | ECOD (1.6) |
H [auth G] | PK_2nd | e1pklG4 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: PK beta-barrel domain-like | F: PK_2nd | ECOD (1.6) |
H [auth G] | PK_1st | e1pklG2 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: PK_1st | ECOD (1.6) |
H [auth G] | PK_C | e1pklG1 | A: a/b three-layered sandwiches | X: PK C-terminal domain-like (From Topology) | H: PK C-terminal domain-like (From Topology) | T: PK C-terminal domain-like | F: PK_C | ECOD (1.6) |
C | PK_2nd | e1pklC4 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: PK beta-barrel domain-like | F: PK_2nd | ECOD (1.6) |
C | PK_1st | e1pklC2 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: PK_1st | ECOD (1.6) |
C | PK_C | e1pklC1 | A: a/b three-layered sandwiches | X: PK C-terminal domain-like (From Topology) | H: PK C-terminal domain-like (From Topology) | T: PK C-terminal domain-like | F: PK_C | ECOD (1.6) |
F | PK_2nd | e1pklF4 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: PK beta-barrel domain-like | F: PK_2nd | ECOD (1.6) |
F | PK_1st | e1pklF2 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: PK_1st | ECOD (1.6) |
F | PK_C | e1pklF1 | A: a/b three-layered sandwiches | X: PK C-terminal domain-like (From Topology) | H: PK C-terminal domain-like (From Topology) | T: PK C-terminal domain-like | F: PK_C | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00224 | Pyruvate kinase, barrel domain (PK) | Pyruvate kinase, barrel domain | This is the barrel domain of pyruvate kinases. This domain represents the beta/alpha barrel and the small beta-barrel domain inserted within it. The active site is found in a cleft between the two domains [1,2,3,4]. | Domain | |
PF02887 | Pyruvate kinase, alpha/beta domain (PK_C) | Pyruvate kinase, alpha/beta domain | Pyruvate kinase catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP [1,2]. The structure of several pyruvate kinases from various organisms have been determined [2, ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR015795 | Pyruvate kinase, C-terminal | Domain | |
IPR015813 | Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily | Homologous Superfamily | |
IPR011037 | Pyruvate kinase-like, insert domain superfamily | Homologous Superfamily | |
IPR015806 | Pyruvate kinase, insert domain superfamily | Homologous Superfamily | |
IPR036918 | Pyruvate kinase, C-terminal domain superfamily | Homologous Superfamily | |
IPR001697 | Pyruvate kinase | Family | |
IPR018209 | Pyruvate kinase, active site | Active Site | |
IPR040442 | Pyruvate kinase-like domain superfamily | Homologous Superfamily | |
IPR015793 | Pyruvate kinase, barrel | Domain |