Annotations: 1N62

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1n62a1	All alpha proteins	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	Carbon monoxide (CO) dehydrogenase iron-sulfur protein, C-domain	(Afipia carboxidovorans OM5 ) [TaxId: 504832 ],	SCOPe (2.08)
A	d1n62a2	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	2Fe-2S ferredoxin domains from multidomain proteins	Carbone monoxide (CO) dehydrogenase iron-sulfur protein, N-domain	(Afipia carboxidovorans OM5 ) [TaxId: 504832 ],	SCOPe (2.08)
D	d1n62d1	All alpha proteins	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	CO dehydrogenase ISP C-domain like	Carbon monoxide (CO) dehydrogenase iron-sulfur protein, C-domain	(Afipia carboxidovorans OM5 ) [TaxId: 504832 ],	SCOPe (2.08)
D	d1n62d2	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	2Fe-2S ferredoxin domains from multidomain proteins	Carbone monoxide (CO) dehydrogenase iron-sulfur protein, N-domain	(Afipia carboxidovorans OM5 ) [TaxId: 504832 ],	SCOPe (2.08)
C	d1n62c1	Alpha and beta proteins (a+b)	CO dehydrogenase flavoprotein C-domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	Carbon monoxide (CO) dehydrogenase flavoprotein, C-terminal domain	(Afipia carboxidovorans OM5 ) [TaxId: 504832 ],	SCOPe (2.08)
C	d1n62c2	Alpha and beta proteins (a+b)	FAD-binding/transporter-associated domain-like	FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein N-terminal domain-like	Carbon monoxide (CO) dehydrogenase flavoprotein, N-terminal domain	(Afipia carboxidovorans OM5 ) [TaxId: 504832 ],	SCOPe (2.08)
F	d1n62f1	Alpha and beta proteins (a+b)	CO dehydrogenase flavoprotein C-domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	CO dehydrogenase flavoprotein C-terminal domain-like	Carbon monoxide (CO) dehydrogenase flavoprotein, C-terminal domain	(Afipia carboxidovorans OM5 ) [TaxId: 504832 ],	SCOPe (2.08)
F	d1n62f2	Alpha and beta proteins (a+b)	FAD-binding/transporter-associated domain-like	FAD-binding/transporter-associated domain-like	CO dehydrogenase flavoprotein N-terminal domain-like	Carbon monoxide (CO) dehydrogenase flavoprotein, N-terminal domain	(Afipia carboxidovorans OM5 ) [TaxId: 504832 ],	SCOPe (2.08)
B	d1n62b1	Alpha and beta proteins (a+b)	alpha/beta-Hammerhead	CO dehydrogenase molybdoprotein N-domain-like	CO dehydrogenase molybdoprotein N-domain-like	Carbon monoxide (CO) dehydrogenase molybdoprotein, N-domain	(Afipia carboxidovorans OM5 ) [TaxId: 504832 ],	SCOPe (2.08)
B	d1n62b2	Alpha and beta proteins (a+b)	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	Carbon monoxide (CO) dehydrogenase molybdoprotein	(Afipia carboxidovorans OM5 ) [TaxId: 504832 ],	SCOPe (2.08)
E	d1n62e1	Alpha and beta proteins (a+b)	alpha/beta-Hammerhead	CO dehydrogenase molybdoprotein N-domain-like	CO dehydrogenase molybdoprotein N-domain-like	Carbon monoxide (CO) dehydrogenase molybdoprotein, N-domain	(Afipia carboxidovorans OM5 ) [TaxId: 504832 ],	SCOPe (2.08)
E	d1n62e2	Alpha and beta proteins (a+b)	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	Molybdenum cofactor-binding domain	Carbon monoxide (CO) dehydrogenase molybdoprotein	(Afipia carboxidovorans OM5 ) [TaxId: 504832 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	CO dehydrogenase ISP C-domain like	8031148	4001010	SCOP2 (2022-06-29)
A	SCOP2 Family	2Fe-2S ferredoxin domains from multidomain proteins	8031150	4000241	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	CO dehydrogenase ISP C-domain like	8043526	3000439	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	2Fe-2S ferredoxin-like	8043528	3000113	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	2Fe-2S ferredoxin-like	8043528	3000113	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	CO dehydrogenase ISP C-domain like	8043526	3000439	SCOP2B (2022-06-29)
C	SCOP2 Family	CO dehydrogenase flavoprotein C-terminal domain-like	8031154	4001591	SCOP2 (2022-06-29)
C	SCOP2 Family	CO dehydrogenase flavoprotein N-terminal domain-like	8031156	4002187	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	CO dehydrogenase flavoprotein C-terminal domain-like	8043532	3001921	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	FAD-binding/transporter-associated domain-like	8043534	3000913	SCOP2 (2022-06-29)
F	SCOP2B Superfamily	CO dehydrogenase flavoprotein C-terminal domain-like	8043532	3001921	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	FAD-binding/transporter-associated domain-like	8043534	3000913	SCOP2B (2022-06-29)
B	SCOP2 Family	CO dehydrogenase molybdoprotein N-domain-like	8031152	4001129	SCOP2 (2022-06-29)
B	SCOP2 Family	Molybdenum cofactor-binding domain	8031153	4001972	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	CO dehydrogenase molybdoprotein N-domain-like	8043530	3000847	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Molybdenum cofactor-binding domain	8043531	3000625	SCOP2 (2022-06-29)
E	SCOP2B Superfamily	CO dehydrogenase molybdoprotein N-domain-like	8043530	3000847	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Molybdenum cofactor-binding domain	8043531	3000625	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Fer2_2	e1n62A1	A: alpha bundles	X: CO dehydrogenase ISP C-domain like (From Topology)	H: CO dehydrogenase ISP C-domain like (From Topology)	T: CO dehydrogenase ISP C-domain like	F: Fer2_2	ECOD (1.6)
A	Fer2_3	e1n62A2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2_3	ECOD (1.6)
D	Fer2_2	e1n62D1	A: alpha bundles	X: CO dehydrogenase ISP C-domain like (From Topology)	H: CO dehydrogenase ISP C-domain like (From Topology)	T: CO dehydrogenase ISP C-domain like	F: Fer2_2	ECOD (1.6)
D	Fer2_3	e1n62D2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2_3	ECOD (1.6)
C	CO_deh_flav_C	e1n62C1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: SufE/NifU (From Topology)	T: SufE/NifU	F: CO_deh_flav_C	ECOD (1.6)
C	FAD_binding_5	e1n62C2	A: a+b complex topology	X: FAD-binding domain-like	H: FAD-binding domain (From Topology)	T: FAD-binding domain	F: FAD_binding_5	ECOD (1.6)
F	CO_deh_flav_C	e1n62F1	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: SufE/NifU (From Topology)	T: SufE/NifU	F: CO_deh_flav_C	ECOD (1.6)
F	FAD_binding_5	e1n62F2	A: a+b complex topology	X: FAD-binding domain-like	H: FAD-binding domain (From Topology)	T: FAD-binding domain	F: FAD_binding_5	ECOD (1.6)
B	Ald_Xan_dh_C2	e1n62B3	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Molybdenum cofactor-binding domain	F: Ald_Xan_dh_C2	ECOD (1.6)
B	Ald_Xan_dh_C	e1n62B2	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: Ald_Xan_dh_C	ECOD (1.6)
E	Ald_Xan_dh_C2	e1n62E3	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Molybdenum cofactor-binding domain	F: Ald_Xan_dh_C2	ECOD (1.6)
E	Ald_Xan_dh_C	e1n62E2	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: Ald_Xan_dh_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (4.3.0)
A	1.10.150.120	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
D	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (4.3.0)
D	1.10.150.120	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
C	3.30.43.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 2	CATH (4.3.0)
C	3.30.390.50	Alpha Beta	2-Layer Sandwich	Enolase-like	domain 1	CATH (4.3.0)
C	3.30.465.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 3	CATH (4.3.0)
F	3.30.43.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 2	CATH (4.3.0)
F	3.30.390.50	Alpha Beta	2-Layer Sandwich	Enolase-like	domain 1	CATH (4.3.0)
F	3.30.465.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 3	CATH (4.3.0)
B	3.90.1170.50	Alpha Beta	Alpha-Beta Complex	Aldehyde Oxidoreductase	domain 3	CATH (4.3.0)
B	3.30.365.10	Alpha Beta	2-Layer Sandwich	Aldehyde Oxidoreductase	domain 4	CATH (4.3.0)
E	3.90.1170.50	Alpha Beta	Alpha-Beta Complex	Aldehyde Oxidoreductase	domain 3	CATH (4.3.0)
E	3.30.365.10	Alpha Beta	2-Layer Sandwich	Aldehyde Oxidoreductase	domain 4	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF01799	[2Fe-2S] binding domain (Fer2_2)	[2Fe-2S] binding domain	-	Domain
A, D	PF00111	2Fe-2S iron-sulfur cluster binding domain (Fer2)	2Fe-2S iron-sulfur cluster binding domain	-	Domain
C, F	PF00941	FAD binding domain in molybdopterin dehydrogenase (FAD_binding_5)	FAD binding domain in molybdopterin dehydrogenase	-	Family
C, F	PF03450	CO dehydrogenase flavoprotein C-terminal domain (CO_deh_flav_C)	CO dehydrogenase flavoprotein C-terminal domain	-	Domain
B, E	PF01315	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain (Ald_Xan_dh_C)	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	Domain
B, E	PF20256	Molybdopterin cofactor-binding domain (MoCoBD_2)	Molybdopterin cofactor-binding domain	-	Domain
B, E	PF02738	Molybdopterin cofactor-binding domain (MoCoBD_1)	Molybdopterin cofactor-binding domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	Carbon monoxide dehydrogenase small chain	iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity carbon-monoxide oxygenase activity cation binding ion binding metal ion binding	-	-
C, F	Carbon monoxide dehydrogenase medium chain	oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity carbon-monoxide oxygenase activity FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity carbon-monoxide oxygenase activity FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding	-	-
B, E	Carbon monoxide dehydrogenase large chain	anaerobic carbon-monoxide dehydrogenase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity cation binding transition metal ion binding copper ion binding ion binding binding metal ion binding small molecule binding molybdenum ion binding oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor anaerobic carbon-monoxide dehydrogenase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity cation binding transition metal ion binding copper ion binding ion binding binding metal ion binding small molecule binding molybdenum ion binding oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor carbon-monoxide oxygenase activity iron ion binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR002888	[2Fe-2S]-binding	Domain
A, D	IPR036010	2Fe-2S ferredoxin-like superfamily	Homologous Superfamily
A, D	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain	Domain
A, D	IPR036884	[2Fe-2S]-binding domain superfamily	Homologous Superfamily
A, D	IPR051452	Diverse Oxidoreductases	Family
A, D	IPR012675	Beta-grasp domain superfamily	Homologous Superfamily
C, F	IPR016167	FAD-binding, type PCMH, subdomain 1	Homologous Superfamily
C, F	IPR036683	CO dehydrogenase flavoprotein, C-terminal domain superfamily	Homologous Superfamily
C, F	IPR051312	Diverse Substrate Oxidoreductases	Family
C, F	IPR036318	FAD-binding, type PCMH-like superfamily	Homologous Superfamily
C, F	IPR016169	FAD-binding, type PCMH, subdomain 2	Homologous Superfamily
C, F	IPR016166	FAD-binding domain, PCMH-type	Domain
C, F	IPR005107	CO dehydrogenase flavoprotein, C-terminal	Domain
C, F	IPR002346	Molybdopterin dehydrogenase, FAD-binding	Domain
B, E	IPR046867	Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain	Domain
B, E	IPR000674	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead	Domain
B, E	IPR012780	Carbon-monoxide dehydrogenase, large subunit	Family
B, E	IPR016208	Aldehyde oxidase/xanthine dehydrogenase-like	Family
B, E	IPR036856	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily	Homologous Superfamily
B, E	IPR037165	Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily	Homologous Superfamily
B, E	IPR008274	Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain	Domain

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
B	aerobic carbon monoxide dehydrogenase M-CSA #107	Carbon monoxide dehydrogenase (CODH), a member of the xanthine oxidase family based on its overall amino acid sequence and three-dimensional structure, catalyses the reversible oxidation of carbon monoxide to carbon dioxide with the loss of two electrons to a variety of electron acceptors can be used by these enzymes including ferredoxin, methyl viologen and benzyl viologen. The CO₂ that is produced is assimilated by the Calvin-Benson-Basham cycle, while the electrons are transferred to a quinone via the FAD site, and continue through the electron transfer chain to a dioxygen terminal acceptor. Under aerobic conditions carbon monoxide can be used as sole carbon and energy source by the carboxidotrophic bacteria, a taxonomically diverse group of obligate or facultative chemolithoautotrophic species. The aerobic enzymes (this entry) categorised so far are molybdenum-containing iron-sulphur proteins whilst the anerobic dehydrogenases are mostly nickel-containing iron-sulphur enzymes. CODH is a dimer of heterotrimers, where each heterotrimer consists of a small iron-sulphur subunit, a medium FAD-containing flavoprotein subunit and a large molybdopterin-containign subunit which contains the active site [PMID:10430865, PMID:12475995]. The large subunit is divided into two domains. The N-terminal domain is composed of mainly of a five-and four-stranded mixed beta-sheet and interacts with the small and medium subunits. The C-terminal domain contains a region which interacts with its counterpart in the overall dimer, providing the main dimer contact, and a beta-sheet surrounded by alpha helices. The active site located in the large subunit and contains a novel dinuclear heterometal [CuSMo(=O)OH] cluster.	Defined by 4 residues: GLN:B-240ARG:B-387CYS:B-388GLU:B-763 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 1.2.99.2 (PDB Primary Data) Search M-CSA Motif + EC 1.2.99.2 EC: 1.2.5.3 (UniProt) Search M-CSA Motif + EC 1.2.5.3