Annotations: 1JAD

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1jada_	Coiled coil proteins	Antiparallel coiled-coil	C-terminal domain of PLC-beta	C-terminal domain of PLC-beta	C-terminal domain of PLC-beta	turkey (Meleagris gallopavo ) [TaxId: 9103 ],	SCOPe (2.08)
B	d1jadb_	Coiled coil proteins	Antiparallel coiled-coil	C-terminal domain of PLC-beta	C-terminal domain of PLC-beta	C-terminal domain of PLC-beta	turkey (Meleagris gallopavo ) [TaxId: 9103 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	C-terminal domain of PLC-beta	8024467	4003668	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	C-terminal domain of PLC-beta	8036846	3001228	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	C-terminal domain of PLC-beta	8036846	3001228	SCOP2B (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1230.10	Mainly Alpha	Up-down Bundle	Phospholipase C Beta	Chain: A	CATH (4.3.0)
B	1.20.1230.10	Mainly Alpha	Up-down Bundle	Phospholipase C Beta	Chain: A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF08703	PLC-beta C terminal (PLC-beta_C)	PLC-beta C terminal	This domain corresponds to the alpha helical C terminal domain of phospholipase C beta.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	phospholipase C beta	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity phospholipase C activity hydrolase activity phosphatidylinositol-4,5-bisphosphate phospholipase C activity catalytic activity phospholipase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity phospholipase C activity hydrolase activity phosphatidylinositol-4,5-bisphosphate phospholipase C activity catalytic activity phospholipase activity lipase activity	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication phosphatidylinositol-mediated signaling cellular process signal transduction lipid catabolic process catabolic process metabolic process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication phosphatidylinositol-mediated signaling cellular process signal transduction lipid catabolic process catabolic process metabolic process primary metabolic process lipid metabolic process regulation of localization cellular localization inorganic ion homeostasis intracellular calcium ion homeostasis transport homeostatic process monoatomic ion transmembrane transport negative regulation of biological process calcium ion homeostasis negative regulation of sequestering of calcium ion calcium ion transport metal ion transport maintenance of location in cell monoatomic cation transmembrane transport localization intracellular monoatomic cation homeostasis monoatomic ion homeostasis negative regulation of cellular process monoatomic ion transport intracellular chemical homeostasis monoatomic cation homeostasis monoatomic cation transport regulation of sequestering of calcium ion intracellular monoatomic ion homeostasis calcium ion transmembrane import into cytosol sequestering of calcium ion inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol cellular homeostasis chemical homeostasis calcium ion transmembrane transport phosphatidylinositol metabolic process glycerophospholipid metabolic process phospholipid metabolic process organophosphate metabolic process phosphate-containing compound metabolic process glycerolipid metabolic process phosphorus metabolic process G protein-coupled receptor signaling pathway	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR028403	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2, catalytic domain	Domain
A, B	IPR053945	Phosphoinositide phospholipase C beta 1-4-like, EF-hand domain	Domain
A, B	IPR001192	Phosphoinositide phospholipase C family	Family
A, B	IPR016280	Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta	Family
A, B	IPR042531	Phospholipase C-beta, C-terminal domain superfamily	Homologous Superfamily
A, B	IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain	Domain
A, B	IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily	Homologous Superfamily
A, B	IPR014815	Phospholipase C-beta, C-terminal domain	Domain
A, B	IPR000008	C2 domain	Domain
A, B	IPR035892	C2 domain superfamily	Homologous Superfamily
A, B	IPR000909	Phosphatidylinositol-specific phospholipase C, X domain	Domain
A, B	IPR046969	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2, EF-hand domain	Domain
A, B	IPR011992	EF-hand domain pair	Homologous Superfamily
A, B	IPR037862	PLC-beta, PH domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.