1INZ | pdb_00001inz

SOLUTION STRUCTURE OF THE EPSIN N-TERMINAL HOMOLOGY (ENTH) DOMAIN OF HUMAN EPSIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1inza1	All alpha proteins	alpha-alpha superhelix	ENTH/VHS domain	ENTH domain	Epsin 1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1inza2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	ENTH domain	8021743	4001355	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ENTH/VHS domain-like	8034123	3000164	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ENTH	e1inzA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ENTH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.90	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01417	ENTH domain (ENTH)	ENTH domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	EPS15-INTERACTING PROTEIN(EPSIN)	clathrin binding protein binding binding molecular sequestering activity phospholipid binding lipid binding	developmental process multicellular organism development multicellular organismal process anatomical structure development animal organ development embryonic organ development embryo development regulation of sprouting angiogenesis regulation of developmental process negative regulation of biological process angiogenesis regulation of vasculature development tube morphogenesis regulation of multicellular organismal process developmental process multicellular organism development multicellular organismal process anatomical structure development animal organ development embryonic organ development embryo development regulation of sprouting angiogenesis regulation of developmental process negative regulation of biological process angiogenesis regulation of vasculature development tube morphogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development regulation of multicellular organismal development regulation of biological process blood vessel morphogenesis tube development negative regulation of blood vessel morphogenesis negative regulation of developmental process biological regulation negative regulation of angiogenesis sprouting angiogenesis vasculature development circulatory system development anatomical structure morphogenesis negative regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis negative regulation of multicellular organismal process negative regulation of sprouting angiogenesis multi-multicellular organism process reproductive process female pregnancy multi-organism reproductive process localization import into cell transport cellular process endocytosis establishment of localization vesicle-mediated transport cellular response to stimulus regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling cell communication Notch signaling pathway signal transduction embryo development ending in birth or egg hatching chordate embryonic development in utero embryonic development	cellular anatomical structure clathrin-coated pit membrane endomembrane system membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle cellular anatomical structure clathrin-coated pit membrane endomembrane system membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle cytosol cell periphery plasma membrane protein-containing complex vesicle coat membrane protein complex membrane coat bounding membrane of organelle vesicle membrane clathrin-coated vesicle clathrin vesicle coat coated vesicle clathrin-coated vesicle membrane coated membrane clathrin coat coated vesicle membrane cytoplasmic vesicle membrane organelle membrane nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008942	ENTH/VHS	Homologous Superfamily
A	IPR013809	ENTH domain	Domain
A	IPR003903	Ubiquitin interacting motif	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9Y6I3	Sjogren syndrome

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.