1GXU

Hydrogenase Maturation Protein HypF "acylphosphatase-like" N-terminal domain (HypF-ACP) in complex with a substrate. Crystal grown in the presence of carbamoylphosphate

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1gxua_	Alpha and beta proteins (a+b)	Ferredoxin-like	Acylphosphatase/BLUF domain-like	Acylphosphatase-like	Hydrogenase maturation protein HypF N-terminal domain (HypF-ACP)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Acylphosphatase/BLUF domain-like	8042299	3000165	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Acylphosphatase	e1gxuA1	A: a+b two layers	X: Alpha-beta plaits	H: Acylphosphatase-like (From Topology)	T: Acylphosphatase-like	F: Acylphosphatase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.70.100	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00708	Acylphosphatase (Acylphosphatase)	Acylphosphatase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	HYDROGENASE MATURATION PROTEIN HYPF	RNA binding double-stranded RNA binding binding organic cyclic compound binding nucleic acid binding carboxyl- or carbamoyltransferase activity transferase activity, transferring one-carbon groups transferase activity catalytic activity ligase activity cation binding transition metal ion binding zinc ion binding ion binding RNA binding double-stranded RNA binding binding organic cyclic compound binding nucleic acid binding carboxyl- or carbamoyltransferase activity transferase activity, transferring one-carbon groups transferase activity catalytic activity ligase activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis macromolecule modification metabolic process primary metabolic process protein carbamoylation protein metabolic process macromolecule metabolic process protein modification process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis macromolecule modification metabolic process primary metabolic process protein carbamoylation protein metabolic process macromolecule metabolic process protein modification process biosynthetic process gene expression macromolecule biosynthetic process protein maturation	ATPase complex protein-containing complex catalytic complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR041440	HypF, Kae1-like domain	Domain
A	IPR051060	Carbamoyltransferase HypF-like	Family
A	IPR036046	Acylphosphatase-like domain superfamily	Homologous Superfamily
A	IPR004421	Carbamoyltransferase, HypF-type	Family
A	IPR055128	Carbamoyltransferase, Kae1-like domain, second subdomain	Domain
A	IPR017945	DHBP synthase RibB-like alpha/beta domain superfamily	Homologous Superfamily
A	IPR006070	Threonylcarbamoyl-AMP synthase-like domain	Domain
A	IPR011125	Zinc finger, HypF-type	Domain
A	IPR017968	Acylphosphatase, conserved site	Conserved Site
A	IPR001792	Acylphosphatase-like domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.