1FIO | pdb_00001fio

CRYSTAL STRUCTURE OF YEAST T-SNARE PROTEIN SSO1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1fioa_	All alpha proteins	STAT-like	t-snare proteins	t-snare proteins	Sso1	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	t-snare proteins	8025207	4000986	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	t-snare proteins	8037586	3000366	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Syntaxin	e1fioA1	A: alpha bundles	X: STAT-like	H: t-snare proteins (From Topology)	T: t-snare proteins	F: Syntaxin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.58.70	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00804	Syntaxin (Syntaxin)	Syntaxin	Syntaxins are the prototype family of SNARE proteins. They usually consist of three main regions - a C-terminal transmembrane region, a central SNARE domain which is characteristic of and conserved in all syntaxins (Pfam:PF05739), and an N-terminal d ...	Syntaxins are the prototype family of SNARE proteins. They usually consist of three main regions - a C-terminal transmembrane region, a central SNARE domain which is characteristic of and conserved in all syntaxins (Pfam:PF05739), and an N-terminal domain that is featured in this entry. This domain varies between syntaxin isoforms; in syntaxin 1A (Swiss:O35526) it is found as three alpha-helices with a left-handed twist. It may fold back on the SNARE domain to allow the molecule to adopt a 'closed' configuration that prevents formation of the core fusion complex - it thus has an auto-inhibitory role. The function of syntaxins is determined by their localisation. They are involved in neuronal exocytosis, ER-Golgi transport and Golgi-endosome transport, for example. They also interact with other proteins as well as those involved in SNARE complexes. These include vesicle coat proteins, Rab GTPases, and tethering factors [6].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	SSO1 PROTEIN	phosphatidylinositol-3,5-bisphosphate binding binding ion binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding phosphatidic acid binding SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity phosphatidylinositol-3,5-bisphosphate binding binding ion binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding phosphatidic acid binding SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity phosphatidylinositol-4,5-bisphosphate binding protein binding SNARE binding phosphatidylinositol-3,4-bisphosphate binding	Golgi to plasma membrane transport cellular localization post-Golgi vesicle-mediated transport transport localization within membrane establishment of localization vesicle-mediated transport vesicle-mediated transport to the plasma membrane localization cellular process Golgi vesicle transport membrane organization protein-containing complex organization membrane fusion Golgi to plasma membrane transport cellular localization post-Golgi vesicle-mediated transport transport localization within membrane establishment of localization vesicle-mediated transport vesicle-mediated transport to the plasma membrane localization cellular process Golgi vesicle transport membrane organization protein-containing complex organization membrane fusion organelle membrane fusion cellular component organization cellular component biogenesis vesicle organization organelle fusion organelle organization cellular component assembly protein-containing complex assembly SNARE complex assembly cellular component organization or biogenesis vesicle fusion vesicle fusion to plasma membrane secretion export from cell secretion by cell exocytosis exocytic process developmental process sporulation Golgi vesicle fusion to target membrane protein localization establishment of protein localization nitrogen compound transport intracellular transport protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization intracellular protein transport sexual sporulation resulting in formation of a cellular spore sexual reproduction cellular developmental process reproductive process reproductive process in single-celled organism meiotic cell cycle cell development developmental process involved in reproduction meiotic cell cycle process sporulation resulting in formation of a cellular spore anatomical structure morphogenesis ascospore formation sexual sporulation cell differentiation anatomical structure formation involved in morphogenesis anatomical structure development cell cycle cell cycle process cellular component assembly involved in morphogenesis cellular anatomical entity morphogenesis ascospore-type prospore assembly organelle localization by membrane tethering organelle localization vesicle docking membrane docking	cellular anatomical structure endomembrane system SNARE complex protein-containing complex intracellular anatomical structure membrane membrane protein complex cytoplasm cell periphery plasma membrane vacuolar membrane membrane-bounded organelle storage vacuole lytic vacuole cellular anatomical structure endomembrane system SNARE complex protein-containing complex intracellular anatomical structure membrane membrane protein complex cytoplasm cell periphery plasma membrane vacuolar membrane membrane-bounded organelle storage vacuole lytic vacuole vacuole intracellular membrane-bounded organelle fungal-type vacuole intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle organelle membrane fungal-type vacuole membrane Golgi membrane Golgi apparatus ascospore-type prospore prospore membrane intracellular immature spore

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000727	Target SNARE coiled-coil homology domain	Domain
A	IPR006012	Syntaxin/epimorphin, conserved site	Conserved Site
A	IPR010989	SNARE	Homologous Superfamily
A	IPR006011	Syntaxin, N-terminal domain	Domain
A	IPR045242	Syntaxin	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.