1DCH | pdb_00001dch

CRYSTAL STRUCTURE OF DCOH, A BIFUNCTIONAL, PROTEIN-BINDING TRANSCRIPTION COACTIVATOR

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1dchb_	Alpha and beta proteins (a+b)	DCoH-like	PCD-like	PCD-like	Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
E	d1dche_	Alpha and beta proteins (a+b)	DCoH-like	PCD-like	PCD-like	Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
A	d1dcha_	Alpha and beta proteins (a+b)	DCoH-like	PCD-like	PCD-like	Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C	d1dchc_	Alpha and beta proteins (a+b)	DCoH-like	PCD-like	PCD-like	Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D	d1dchd_	Alpha and beta proteins (a+b)	DCoH-like	PCD-like	PCD-like	Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
F	d1dchf_	Alpha and beta proteins (a+b)	DCoH-like	PCD-like	PCD-like	Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
G	d1dchg_	Alpha and beta proteins (a+b)	DCoH-like	PCD-like	PCD-like	Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
H	d1dchh_	Alpha and beta proteins (a+b)	DCoH-like	PCD-like	PCD-like	Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	PCD-like	8035863	3001639	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	PCD-like	8035863	3001639	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PCD-like	8035863	3001639	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PCD-like	8035863	3001639	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PCD-like	8035863	3001639	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	PCD-like	8035863	3001639	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	PCD-like	8035863	3001639	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	PCD-like	8035863	3001639	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Pterin_4a	e1dchB1	A: a+b two layers	X: DCoH-like	H: Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) (From Topology)	T: Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)	F: Pterin_4a	ECOD (1.6)
E	Pterin_4a	e1dchE1	A: a+b two layers	X: DCoH-like	H: Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) (From Topology)	T: Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)	F: Pterin_4a	ECOD (1.6)
A	Pterin_4a	e1dchA1	A: a+b two layers	X: DCoH-like	H: Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) (From Topology)	T: Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)	F: Pterin_4a	ECOD (1.6)
C	Pterin_4a	e1dchC1	A: a+b two layers	X: DCoH-like	H: Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) (From Topology)	T: Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)	F: Pterin_4a	ECOD (1.6)
D	Pterin_4a	e1dchD1	A: a+b two layers	X: DCoH-like	H: Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) (From Topology)	T: Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)	F: Pterin_4a	ECOD (1.6)
F	Pterin_4a	e1dchF1	A: a+b two layers	X: DCoH-like	H: Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) (From Topology)	T: Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)	F: Pterin_4a	ECOD (1.6)
G	Pterin_4a	e1dchG1	A: a+b two layers	X: DCoH-like	H: Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) (From Topology)	T: Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)	F: Pterin_4a	ECOD (1.6)
H	Pterin_4a	e1dchH1	A: a+b two layers	X: DCoH-like	H: Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) (From Topology)	T: Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)	F: Pterin_4a	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.1360.20	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
E	3.30.1360.20	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
A	3.30.1360.20	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
C	3.30.1360.20	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
D	3.30.1360.20	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
F	3.30.1360.20	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
G	3.30.1360.20	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
H	3.30.1360.20	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF01329	Pterin 4 alpha carbinolamine dehydratase (Pterin_4a)	Pterin 4 alpha carbinolamine dehydratase	Pterin 4 alpha carbinolamine dehydratase is also known as DCoH (dimerisation cofactor of hepatocyte nuclear factor 1-alpha).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	DCOH (DIMERIZATION COFACTOR OF HNF-1)	transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen phenylalanine 4-monooxygenase activity catalytic activity 4-alpha-hydroxytetrahydrobiopterin dehydratase activity hydro-lyase activity lyase activity transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen phenylalanine 4-monooxygenase activity catalytic activity 4-alpha-hydroxytetrahydrobiopterin dehydratase activity hydro-lyase activity lyase activity carbon-oxygen lyase activity identical protein binding protein binding binding	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process aromatic amino acid metabolic process oxoacid metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process L-phenylalanine metabolic process proteinogenic amino acid metabolic process metabolic process cellular process small molecule metabolic process erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process aromatic amino acid metabolic process oxoacid metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process L-phenylalanine metabolic process proteinogenic amino acid metabolic process metabolic process cellular process small molecule metabolic process polyol metabolic process small molecule biosynthetic process alcohol metabolic process diol biosynthetic process diol metabolic process biosynthetic process tetrahydrobiopterin biosynthetic process tetrahydrobiopterin metabolic process pteridine-containing compound biosynthetic process polyol biosynthetic process alcohol biosynthetic process pteridine-containing compound metabolic process regulation of protein binding regulation of molecular function regulation of binding biological regulation regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036428	Pterin 4 alpha carbinolamine dehydratase superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001533	Pterin 4 alpha carbinolamine dehydratase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.