8STG | pdb_00008stg

Discovery and clinical validation of RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations

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RCSB PDB Mol* Viewer 2.11.4 [4/4/2025, 6:48:47 PM]
Sequence of
     ​S​​H​​M​​G​​S​​P​​M​​L​​A​​G​463  ​V​​S​​E​​Y​​E​​L​​P​​E​​D​​P​473  ​K​​W​​E​​F​​P​​R​​D​​K​​L​​T​483  ​L​​G​​K​​P​​L​​G​​E​​G​​C​​F​493  ​G​​Q​​V​​V​​M​​A​​E​​A​​V​​G​503  ​I​​D​​K​​D​​K​​P​​K​​E​​A​​V​513  ​T​​V​​A​​V​​K​​M​​L​​K​​D​​D​523  ​A​​T​​E​​K​​D​​L​​S​​D​​L​​V​533  ​S​​E​​M​​E​​M​​M​​K​​M​​I​​G​543  ​K​​H​​K​​N​​I​​I​​N​​L​​L​​G​553  ​A​​C​​T​​Q​​D​​G​​P​​L​​Y​​V​563  ​I​​V​​E​​Y​​A​​S​​K​​G​​N​​L​573  ​R​​E​​Y​​L​​R​​A​​R​​R​​P​​P​     ​G​​M​​E​​Y​​S​​Y​​D​​I​​N​​R​593  ​V​​P​​E​​E​​Q​​M​​T​​F​​K​​D​603  ​L​​V​​S​​C​​T​​Y​​Q​​L​​A​​R​613  ​G​​M​​E​​Y​​L​​A​​S​​Q​​K​​C​623  ​I​​H​​R​​D​​L​​A​​A​​R​​N​​V​633  ​L​​V​​T​​E​​N​​N​​V​​M​​K​​I​643  ​A​​D​​F​​G​​L​​A​​R​​D​​I​​N​     ​N​​I​​D​​Y​​Y​​K​​K​​T​​T​​N​     ​G​​R​​L​​P​​V​​K​​W​​M​​A​​P​673  ​E​​A​​L​​F​​D​​R​​V​​Y​​T​​H​683  ​Q​​S​​D​​V​​W​​S​​F​​G​​V​​L​693  ​M​​W​​E​​I​​F​​T​​L​​G​​G​​S​703  ​P​​Y​​P​​G​​I​​P​​V​​E​​E​​L​713  ​F​​K​​L​​L​​K​​E​​G​​H​​R​​M​723  ​D​​K​​P​​A​​N​​C​​T​​N​​E​​L​733  ​Y​​M​​M​​M​​R​​D​​C​​W​​H​​A​743  ​V​​P​​S​​Q​​R​​P​​T​​F​​K​​Q​753  ​L​​V​​E​​D​​L​​D​​R​​I​​L​​T​763  ​L​​T​​T​​N​​E​​E​​Y​
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Asm Id
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