Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Anti-Tumor Agent

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RCSB PDB Mol* Viewer 2.11.4 [4/4/2025, 6:48:47 PM]
Sequence of
     ​G​​A​​M​​G​​S​​P​​G​​D​​G​​A​23   ​G​​A​​S​​R​​Q​​R​​K​​L​​E​​A​33   ​L​​I​​R​​D​​P​​R​​S​​P​​I​​N​43   ​V​​E​​S​​L​​L​​D​​G​​L​​N​​S​53   ​L​​V​​L​​D​​L​​D​​F​​P​​A​​L​63   ​R​​K​​N​​K​​N​​I​​D​​N​​F​​L​73   ​N​​R​​Y​​E​​K​​I​​V​​K​​K​​I​83   ​R​​G​​L​​Q​​M​​K​​A​​E​​D​​Y​93   ​D​​V​​V​​K​​V​​I​​G​​R​​G​​A​103  ​F​​G​​E​​V​​Q​​L​​V​​R​​H​​K​113  ​A​​S​​Q​​K​​V​​Y​​A​​M​​K​​L​123  ​L​​S​​K​​F​​E​​M​​I​​K​​R​​S​133  ​D​​S​​A​​F​​F​​W​​E​​E​​R​​D​143  ​I​​M​​A​​F​​A​​N​​S​​P​​W​​V​153  ​V​​Q​​L​​F​​Y​​A​​F​​Q​​D​​D​163  ​R​​Y​​L​​Y​​M​​V​​M​​E​​Y​​M​173  ​P​​G​​G​​D​​L​​V​​N​​L​​M​​S​183  ​N​​Y​​D​​V​​P​​E​​K​​W​​A​​K​193  ​F​​Y​​T​​A​​E​​V​​V​​L​​A​​L​203  ​D​​A​​I​​H​​S​​M​​G​​L​​I​​H​213  ​R​​D​​V​​K​​P​​D​​N​​M​​L​​L​223  ​D​​K​​H​​G​​H​​L​​K​​L​​A​​D​233  ​F​​G​​T​​C​​M​​K​​M​​D​​E​​T​243  ​G​​M​​V​​H​​C​​D​​T​​A​​V​​G​253  ​T​​P​​D​​Y​​I​​S​​P​​E​​V​​L​263  ​K​​S​​Q​​G​​G​​D​​G​​Y​​Y​​G​273  ​R​​E​​C​​D​​W​​W​​S​​V​​G​​V​283  ​F​​L​​Y​​E​​M​​L​​V​​G​​D​​T​293  ​P​​F​​Y​​A​​D​​S​​L​​V​​G​​T​303  ​Y​​S​​K​​I​​M​​D​​H​​K​​N​​S​313  ​L​​C​​F​​P​​E​​D​​A​​E​​I​​S​323  ​K​​H​​A​​K​​N​​L​​I​​C​​A​​F​333  ​L​​T​​D​​R​​E​​V​​R​​L​​G​​R​343  ​N​​G​​V​​E​​E​​I​​R​​Q​​H​​P​353  ​F​​F​​K​​N​​D​​Q​​W​​H​​W​​D​363  ​N​​I​​R​​E​​T​​A​​A​​P​​V​​V​373  ​P​​E​​L​​S​​S​​D​​I​​D​​S​​S​383  ​N​​F​​D​​D​​I​​E​​D​​D​​K​​G​     ​D​​V​​E​​T​​F​​P​​I​​P​​K​​A​403  ​F​​V​​G​​N​​Q​​L​​P​​F​​I​​G​413  ​F​​T​​Y​​Y​​R​
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Asm Id
Dynamic Bonds

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