5UVC | pdb_00005uvc

Design, Synthesis, and Evaluation of the First Selective and Potent G-protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure

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RCSB PDB Mol* Viewer 2.11.4 [4/4/2025, 6:48:47 PM]
Sequence of
     ​M​​S​​Y​​Y​​H​​H​​H​​H​​H​​H​     ​D​​Y​​D​​I​​P​​T​​T​​E​​N​​L​     ​Y​​F​​Q​​G​​A​​M​​E​​P​​G​​G​     ​S​​T​​P​​A​​A​​R​​A​​S​​K​​K​32   ​I​​L​​L​​P​​E​​P​​S​​I​​R​​S​42   ​V​​M​​Q​​K​​Y​​L​​E​​D​​R​​G​52   ​E​​V​​T​​F​​E​​K​​I​​F​​S​​Q​62   ​K​​L​​G​​Y​​L​​L​​F​​R​​D​​F​72   ​C​​L​​N​​H​​L​​E​​E​​A​​R​​P​82   ​L​​V​​E​​F​​Y​​E​​E​​I​​K​​K​92   ​Y​​E​​K​​L​​E​​T​​E​​E​​E​​R​102  ​V​​A​​R​​S​​R​​E​​I​​F​​D​​S​112  ​Y​​I​​M​​K​​E​​L​​L​​A​​C​​S​     ​H​​P​​F​​S​​K​​S​​A​​T​​E​​H​     ​V​​Q​​G​​H​​L​​G​​K​​K​​Q​​V​142  ​P​​P​​D​​L​​F​​Q​​P​​Y​​I​​E​152  ​E​​I​​C​​Q​​N​​L​​R​​G​​D​​V​162  ​F​​Q​​K​​F​​I​​E​​S​​D​​K​​F​172  ​T​​R​​F​​C​​Q​​W​​K​​N​​V​​E​182  ​L​​N​​I​​H​​L​​T​​M​​N​​D​​F​192  ​S​​V​​H​​R​​I​​I​​G​​R​​G​​G​202  ​F​​G​​E​​V​​Y​​G​​C​​R​​K​​A​212  ​D​​T​​G​​K​​M​​Y​​A​​M​​K​​C​222  ​L​​D​​K​​K​​R​​I​​K​​M​​K​​Q​232  ​G​​E​​T​​L​​A​​L​​N​​E​​R​​I​242  ​M​​L​​S​​L​​V​​S​​T​​G​​D​​C​252  ​P​​F​​I​​V​​C​​M​​S​​Y​​A​​F​262  ​H​​T​​P​​D​​K​​L​​S​​F​​I​​L​272  ​D​​L​​M​​N​​G​​G​​D​​L​​H​​Y​282  ​H​​L​​S​​Q​​H​​G​​V​​F​​S​​E​292  ​A​​D​​M​​R​​F​​Y​​A​​A​​E​​I​302  ​I​​L​​G​​L​​E​​H​​M​​H​​N​​R​312  ​F​​V​​V​​Y​​R​​D​​L​​K​​P​​A​322  ​N​​I​​L​​L​​D​​E​​H​​G​​H​​V​332  ​R​​I​​S​​D​​L​​G​​L​​A​​C​​D​342  ​F​​S​​K​​K​​K​​P​​H​​A​​S​​V​352  ​G​​T​​H​​G​​Y​​M​​A​​P​​E​​V​362  ​L​​Q​​K​​G​​V​​A​​Y​​D​​S​​S​372  ​A​​D​​W​​F​​S​​L​​G​​C​​M​​L​382  ​F​​K​​L​​L​​R​​G​​H​​S​​P​​F​392  ​R​​Q​​H​​K​​T​​K​​D​​K​​H​​E​402  ​I​​D​​R​​M​​T​​L​​T​​M​​A​​V​412  ​E​​L​​P​​D​​S​​F​​S​​P​​E​​L​422  ​R​​S​​L​​L​​E​​G​​L​​L​​Q​​R​432  ​D​​V​​N​​R​​R​​L​​G​​C​​L​​G​442  ​R​​G​​A​​Q​​E​​V​​K​​E​​S​​P​452  ​F​​F​​R​​S​​L​​D​​W​​Q​​M​​V​462  ​F​​L​​Q​​K​​Y​​P​​P​​P​​L​​I​472  ​P​​P​​R​​G​​E​​V​​N​​A​​A​​D​     ​A​​F​​D​​I​​G​​S​​F​​D​​E​​E​     ​D​​T​​K​​G​​I​​K​​L​​L​​D​​S​502  ​D​​Q​​E​​L​​Y​​R​​N​​F​​P​​L​512  ​T​​I​​S​​E​​R​​W​​Q​​Q​​E​​V​522  ​A​​E​​T​​V​​F​​D​​T​​I​​N​​A​532  ​E​​T​​D​​R​​L​​E​​A​
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Asm Id
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