Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP102, a multitargeted kinase inhibitor

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Sequence of
     ​G​​H​​M​​Q​​T​​Q​​G​​L​​A​​K​     ​D​​A​​W​​E​​I​​P​​R​​E​​S​​L​268  ​R​​L​​E​​V​​K​​L​​G​​Q​​G​​C​     ​F​​G​​E​​V​​W​​M​​G​​T​​W​​N​288  ​G​​T​​T​​R​​V​​A​​I​​K​​T​​L​     ​K​​P​​G​​T​​M​​S​​P​​E​​A​​F​     ​L​​Q​​E​​A​​Q​​V​​M​​K​​K​​L​318  ​R​​H​​E​​K​​L​​V​​Q​​L​​Y​​A​328  ​V​​V​​S​​E​​E​​P​​I​​Y​​I​​V​338  ​T​​E​​Y​​M​​S​​K​​G​​S​​L​​L​348  ​D​​F​​L​​K​​G​​E​​M​​G​​K​​Y​358  ​L​​R​​L​​P​​Q​​L​​V​​D​​M​​A​368  ​A​​Q​​I​​A​​S​​G​​M​​A​​Y​​V​378  ​E​​R​​M​​N​​Y​​V​​H​​R​​D​​L​388  ​R​​A​​A​​N​​I​​L​​V​​G​​E​​N​398  ​L​​V​​C​​K​​V​​A​​D​​F​​G​​L​     ​A​​R​​L​​I​​E​​D​​N​​E​​Y​​T​     ​A​​R​​Q​​G​​A​​K​​F​​P​​I​​K​428  ​W​​T​​A​​P​​E​​A​​A​​L​​Y​​G​438  ​R​​F​​T​​I​​K​​S​​D​​V​​W​​S​448  ​F​​G​​I​​L​​L​​T​​E​​L​​T​​T​458  ​K​​G​​R​​V​​P​​Y​​P​​G​​M​​V​468  ​N​​R​​E​​V​​L​​D​​Q​​V​​E​​R​478  ​G​​Y​​R​​M​​P​​C​​P​​P​​E​​C​488  ​P​​E​​S​​L​​H​​D​​L​​M​​C​​Q​498  ​C​​W​​R​​K​​D​​P​​E​​E​​R​​P​508  ​T​​F​​E​​Y​​L​​Q​​A​​F​​L​​E​518  ​D​​Y​​F​​T​​S​​T​​E​​P​​Q​​Y​528  ​Q​​P​​G​​E​​N​​L​
Type
Asm Id
Dynamic Bonds

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